Abstract: Objective: To analyze the clinicopathological features,treatment and prognosis of patients with breast cancer,and investigate the influencing factors of prognosis.Methods: The clinical data of the clinicopathological characteristics,recurrence,metastasis and survival in 338 breast cancer patients diagnosed by pathology were retrospectively analyzed,and the influencing prognosis factor was investigated by survival analysis.Results: All patients were followed up for 4 to 115 months,and the median follow-up time was 42 months.The 5-year disease-free survival(DFS) and 5-year overall survival(OS) rates were 77.46% and 81.69%,respectively.The univariate analysis indicated that the tumor size,number of lymph node metastasis and radiotherapy were the influencing factors of DFS and OS(P<0.01).The multivariate Cox regression analysis indicated that the tumor size and number of lymph node metastasis were the independent influencing factor of DFS and OS in breast cancer pateints.Conclusions: The tumor size and number of lymph node metastasis are the independent influencing factor of prognosis in patients with breast cancer.